| 品牌 | 其他品牌 | 适用领域 | 科研 |
|---|---|---|---|
| 产地 | 进口 | 加工定制 | 是 |
广州鸿程生物有限公司一家专注于生命科学的科技企业，由在国内科研试剂领域有着丰富从业经验的技术团队和管理团队组建而成，专营进口生物试剂，科学仪器，实验消耗品等。公司将不断把上优质的产品引入国内市场，满足客户的需求，公司也将紧跟生命科学的发展，为广大科研工作者探索生命科学的奥秘奉献绵薄之力.专门从事以抗*Beckman A63881的磁珠 现货，moltox 11-101.5等现货，transgenomic 706020/706025现货
BioLog Life Science 广州鸿程代理
Biolog 是一家总部位于德国的创新型和科学型企业，专注于信号转导研究工具。
这家通过 ISO 9001 认证的公司专注于核苷酸化学，特别强调基于环核苷酸的各种蛋白激酶、磷酸二酯酶和离子通道等调节剂。
许多稀有的高纯度环状 AMP 和 GMP 激动剂和拮抗剂已被开发出来，它们在膜通透性、受体特异性和激酶同工酶选择性方面不同或带有荧光标记。
对于环状核苷酸结合蛋白的亲和层析，也可以使用具有 PDE 稳定配体结构的凝胶。
定制合成和定制纯化，特别是在单磷酸、二磷酸和三磷酸以及荧光标记领域是该公司的其他主要业务。
在 Biolog，对环状核苷酸反应受体的新型特异性调节剂进行了长期研究，这已经导致了几种普遍接受的信号转导研究工具，例如 PKA 和 PKG 抑制剂以及 Epac 特异性激动剂。
该公司还与其他研究小组进行科学合作，主要是在受体定位研究和通过核苷酸类似物开发新型酶调节剂（点击此处查看参考文献列表）。
由于提供的大多数产品都是在自己的实验室合成的，因此在核苷酸化学和相应的科学领域有很强的背景。
Technical Information about c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p]
Update: March 21, 2022
Formula | CAS No. | Molecular Weight | UV | BIOLOG Cat. No. |
C59 H74 N14O21 P2S2 (free acid) | [pending] | 1441.4 (free acid) |
| C 270 |
Name: Cyclic (3'- O- (6- [sulfo-cyanine5]aminohexylcarbamoyl)guanosine- (2' −> 5')- monophosphate- adenosine- (3' −> 5')- monophosphate) sodium salt
Description: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is a fluorescently labelled version of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka cGAMP(2'-5') or 2'3'-cGAMP, Cat. No. C 161) in which the sulfo-Cyanine 5 fluorophore has been attached to the free ribose-3' position of the cyclic structure via an aminohexylcarbamoyl spacer.
Properties: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is fluorescent with 
exc 646 nm and em 662 nm. The parent compound c[G(2',5')pA(3',5')p] (Cat. No. C 161) was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS).
Specification: Crystallized or lyophilized sodium salt. Please keep in mind that equal concentrations of the compound may look different in volume due to sensitivity of the lyophilized form to humidity. The compound can even contract to small volume droplets. Normally the product is located in the conical bottom of the tube. Micromolar quantities are determined by UV/VIS at max .
Purity: Typical analysis is better than 95% (HPLC / UV 258 nm / VIS 646 nm). The product is not sterile and has not been tested for endotoxins.
Solubility: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is soluble in water (≥ 1 mM, limits have not been determined). Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing. When opening the tube please make sure that no substance is lost within the cap.
Stability and Storage: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is chemically relatively stable. Nevertheless, the compound should be protected from light and stored in the freezer (- 20° Celsius necessary, - 80° recommended), for longer storage periods preferably in freeze-dried form.
Toxicity and Safety: Please keep in mind, that the in vivo properties of this compound are not sufficiently characterized up to now. Avoid skin contact or ingestion and allow only trained personnel to handle the product. Our products are designed, developed and sold for research purposes only! They are intended for in vitro and nonhuman in vivo laboratory applications. Any other use requires approval of health authorities.
Not for drug, household or related uses!
Selected References for c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p]: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is a new product and there are currently no corresponding references available.
Selected References for the Parent Compound c[G(2',5')pA(3',5')p]:
Bridgeman, A.; Maelfait, J.; Davenne, T.; Partridge T.; Peng, Y.; Mayer, A.; Dong, T.; Kaever, V.; Borrow, P.; Rehwinkel J., Science, 349, 1228 - 1232 (2015): "Viruses Transfer the Antiviral Second Messenger cGAMP Between Cells"
Lolicato, M.;Bucchi, A.;Arrigoni, C.;Zucca, S.;Nardini, M.;Schroeder, I.;Simmons, K.;Aquila, M.;DiFrancesco, D.;Bolognesi, M.; Schwede, F.; Kashin, D.;Fishwick, C.W.;Johnson, A.P.;Thiel, G.;Moroni, A., Nat. Chem. Biol., 10, 457 - 462 (2014): "Cyclic Dinucleotides bind the C-linker of HCN4 to Control Channel cAMP Responsiveness"
Konno, H.; Konno, K.; Barber, G.N., Cell, 155 688 - 698 (2013): "Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling"
Ablasser, A.; Schmid-Burgk, J.L.; Hemmerling, I.; Horvath, G.L.; Schmidt, T.; Latz, E.; Hornung, V., Nature, 503, 530 - 534 (2013): "Cell Intrinsic Immunity Spreads to Bystander Cells via the Intercellular Transfer of cGAMP"
Li, X.D.; Wu, J.; Gao, D.; Wang, H.; Sun, L.; Chen, Z.J., Science, 341, 1390 - 1394 (2013): "Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects"
Gao, D.; Wu, J.; Wu, Y.T.; Du, F.; Aroh, C.; Yan, N.; Sun, L.; Chen, Z.J., Science, 341, 903 - 906 (2013): "Cyclic GMP-AMP Synthase is an Innate Immune Sensor of HIV and Other Retroviruses"
Gao, P.; Ascano, M.; Wu, Y.; Barchet, W.; Gaffney, B.L.; Zillinger, T.; Serganov, A.A.; Liu, Y.; Jones R.A.; Hartmann, G.; Tuschl, T.; Patel, D.J., Cell, 153, 1094 - 1107 (2013): "Cyclic [G(2',5')pA(3',5')p] Is the Metazoan Second Messenger Produced by DNA- Activated Cyclic GMP-AMP Synthase"
Ablasser, A.; Goldeck, M.; Cavlar, T.; Deimling T.; Witte, G.; Röhl, I.; Hopfner, K.-P.; Ludwig, J.; Hornung, V., Nature, 498, 380 - 384 (2013): "cGAS Produces a 2'-5'-linked Cyclic Dinucleotide Second Messenger that Activates STING"
Zhang, X.; Shi, H.; Wu, J.; Zhang, X.; Sun, L.; Chen, C.; Chen, Z .J., Mol. Cell, 51, 226 - 235 (2013): "Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING"
Diner, E.J.; Burdette, D.L.; Wilson, S.C.; Monroe, K.M.; Kellenberger, C.A.; Hyodo, M.; Hayakawa, Y.; Hammond, M.C.; Vance, R.E., Cell Rep., 3 1355 - 1361 (2013): "The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING"
Wu, J.;Sun, L.;Chen, X.;Du, F.;Shi, H.;Chen, C.;Chen, Z.J.,Science, 339, 826 - 830 (2013): "Cyclic GMP-AMP is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA"
Sun, L.;Wu, J.;Du, F.;Chen, X.;Chen, Z.J.,Science, 339, 786 - 791 (2013): "Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway"
